Kathleen Brown and Heather Leahy scored a team-high 10 points apiece and Marymount limited Wesley to 21 percent shooting en route to a 51-34 road win.
The victory was the 500th for Saints coach Bill Finney. Finney, who is 500-180 overall, is the third women's coach to reach the 500-win milestone this season, following Roanoke's Susan Dunagan and Washington U's Nancy Fahey. Next on the list is Concordia-Austin's Linda Sharp, with 493 wins.
The Saints are currently ranked No. 25 in Division III and have been to the NCAA Tournament 13 times under Finney, including six trips to the Sweet 16 and one to the Final Four.